Uncommon Histological Variants of Cervical Cancer – A Single Center Experience

Aim: To study the clinical and demographic characteristics of cancers of uterine cervix with histology other than SCC and AC at a tertiary referral hospital in eastern India.

Study Design: Retrospective study.

Place and Duration of Study: Tata Medical Center, Kolkata, India from May 2011 to July 2018.

Methodology: A retrospective review of cases of cervical cancer was done using prospectively collected data from electronic medical records from May 2011 to July 2018. Clinical and demographic characteristics of the cases were noted.

Results: A total of 644 cases of cervical cancer were treated in the study period. 14 cases of uncommon histological types were recorded (NECC – 6, Clear Cell Carcinoma – 1, Mucinous Adenocarcinoma – 3, Serous Carcinoma – 1, Melanoma – 1, Carcinosarcoma – 1 and Adenoma Malignum – 1). The median recurrence free survival for non-metastatic disease population was 24 months and the median 3 year overall survival for non-metastatic disease population 54%.

Conclusion: The prognosis of the uncommon histological types remains poor. However, further prospective studies are required to study the natural history, treatment and prognosis of these tumors.