Chen, Qun and Qi, Steven and Hocum-Stone, Laura and Lesnefsky, Edward and Kelly, Rosemary F. and McFalls, Edward O. (2021) Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone. Antioxidants, 10 (2). p. 276. ISSN 2076-3921
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Abstract
Over 240 million non-cardiac operations occur each year and are associated with a 15–20% incidence of adverse perioperative cardiovascular events. Unfortunately, preoperative therapies that have been useful for chronic ischemic heart diseases, such as coronary artery revascularization, antiplatelet agents, and beta-blockers have failed to improve outcomes. In a pre-clinical swine model of ischemic heart disease, we showed that daily administration of ubiquinone (coenzyme Q10, CoQ10) enhances the antioxidant status of mitochondria within chronically ischemic heart tissue, potentially via a PGC1α-dependent mechanism. In a randomized controlled trial, among high-risk patients undergoing elective vascular surgery, we showed that NT Pro-BNP levels are an important means of risk-stratification during the perioperative period and can be lowered with administration of CoQ10 (400 mg/day) for 3 days prior to surgery. The review provides background information for the role of oxidant stress and inflammation during high-risk operations and the potential novel application of ubiquinone as a preoperative antioxidant therapy that might reduce perioperative adverse cardiovascular outcomes.
Item Type: | Article |
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Subjects: | GO STM Archive > Agricultural and Food Science |
Depositing User: | Unnamed user with email support@gostmarchive.com |
Date Deposited: | 26 Jun 2024 09:58 |
Last Modified: | 26 Jun 2024 09:58 |
URI: | http://journal.openarchivescholar.com/id/eprint/1298 |