Syntheses, Characterization, and Biological Activity of Mixed Antimalaria Metal Complexes

This project deals with the synthesis, spectroscopic characterization and antimicrobial activity of metal complexes with Amodiaquine and pyrimethamine drugs. Five metal complexes derived from amodiaquine and pyrimethamine have been synthesized using the following metal ions: Co(Il), Cu(Il), Zn(Il), Ni(II) and Fe(III). The complexes were characterized by decomposition temperature, solubility, conductivity measurement, elemental analyses, UV-Vis and IR spectroscopy. According to the results of physiochemical and spectroscopic data, the metal complexes were proposed to have the formula: [ML1L2].Y,xH2O (where L= Ligand, M = Cu(II), Ni(II), Zn(II) and Fe(III), Y = SO4 or Cl2.

The complexes have higher melting point than their free ligands and the lower value of conductivity test showed that the complexes are non-electrolytes. The spectroscopic data proposed that Amodiaquine coordinated through the oxygen atoms of the ydroxyl group, and pyrimethamine coordinated through Nitrogen atom of primary amine group. The complexes showed octahedral geometry with the ligands acting as bidentate.

The complexes were evaluated for in vitro antibacterial and antifungal activity against four isolates of Steptococcus faecalis, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. The results show that the synthesized mixed ligands have higher antibacterial activities compared with the original ligands.