THE INFLUENCE OF INDOL DERIVATIVE SS-68 ON SMOOTH MUSCLE CELLS OF INSULATED TRACHEA OF GUINEA PIGS

The substance SS-68 relaxes smooth muscles cells of tracheal rings of guinea pig in vitro. Such effect is selective for β2-adrenergic receptors, and type of this influence depends on method of stimulation on insulated trachea. The duration of effect substance SS-68 is not so long (about 15 min for toning after this exposure in concentration 10-7 M or about 60 min after maximum concentration in compare to super selective β2-adrenomimetic substance indacaterol maleate (the tonus of tracheal rings after washing away the substance SS-68 was not resorted. An amplitude of relaxation smooth-muscle cells on influence of the substance SS-68 in concentration 10-7 M is about 47% of the amplitude of relaxation witch has been maded by indacaterol maleate.