Computer-Aided Design of Anticancer 1,4-Naphthoquinone Derivatives

Ali, Lubna and Saeed, Ahmed (2017) Computer-Aided Design of Anticancer 1,4-Naphthoquinone Derivatives. Chemical Science International Journal, 18 (4). pp. 1-11. ISSN 2456706X

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Official URL: https://doi.org/10.9734/CSJI/2017/31344

Abstract

Aims: Evaluation the impact of p-naphthoquinones upon biological activities and extent based upon QSAR technique.

Study Design: QSAR Approach.

Methodology: About twelve - eleven naphthoquinones which have cytotoxic effect against eight cancer cell lines: L1210, P388, NCI-H358M, OVCAR-8, PC-3M DU145, T24 and MCF7 and partition coefficient descriptor was used to find good QSAR model.

Results: The biological activity and partition coefficient of naphthoquinones can be modeled with linear regression with negative coefficient and good satisfied statistical data for all these cancer cell lines

Conclusion: The inhibition of eight cancer cell lines is influenced mainly by partition coefficient.

Item Type:	Article
Subjects:	GO STM Archive > Chemical Science
Depositing User:	Unnamed user with email support@gostmarchive.com
Date Deposited:	16 May 2023 06:39
Last Modified:	20 Sep 2024 04:10
URI:	http://journal.openarchivescholar.com/id/eprint/777

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