Lidocaine subgingival irrigation modulate the levels of prostaglandin E2 in gingival crevicular fluid after periodontal therapy

Gabriela, Alessandra da Cruz Galhardo Camargo and J otilde ao, Eduardo Marra Fellows and Isis, Andr eacute a Venturini Pola Poiate and Apoena, de Aguiar Ribeiro and Etyene, Castro Dip and Natalia, Linhares Coutinho Silva and Ana, Lu iacute sa Palhares de Miranda and Jorge, Luiz Mendon ccedil a Tributino (2015) Lidocaine subgingival irrigation modulate the levels of prostaglandin E2 in gingival crevicular fluid after periodontal therapy. Journal of Dentistry and Oral Hygiene, 7 (11). pp. 190-196. ISSN 2141-2472

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Abstract

The aim of this study has evaluated if lidocaine 2% with 1:100.000 epinephrine used as subgingival irrigation has anti-inflammatory effect after periodontal therapy. Seventeen patients were selected to this paired split mouth randomized, subject-blind study. Each patient had a minimum of two sites labeled and alleatory separated, both with probe depth ≥ 5 mm. Each site were separated in two groups: scaling and root planing + lidocaine 2% with 1:100.000 epinephrine used as subgingival irrigation (LD); and scaling and root planing + saline solution (SRP), both groups were blinded to the examiner. Clinical periodontal parameters were recorded: plaque index (PI), bleeding on probe (BOP), probing depth (PD), gingival recession (GR) and clinical attachment level (CAL). Levels of GCF-PGE2 were analyzed by enzyme-linked immunosorbent. All parameters were recorded at baseline (1 and 3 months) after periodontal treatment. The results indicated reduction of PI, BOP, PD, CAL for LD and SRP groups and GCF-PGE2 levels were reduced in LD group after 3 months periodontal therapy. The LD and SRP groups were equally efficacious to control the periodontal disease after 3 months. However, LD improved the reduction of PGE2 levels and maintains the inhibitory anti-inflammatory effect on PGE2 after 3 months of periodontal treatment.

Item Type: Article
Subjects: GO STM Archive > Medical Science
Depositing User: Unnamed user with email support@gostmarchive.com
Date Deposited: 16 May 2023 06:39
Last Modified: 06 Jul 2024 07:32
URI: http://journal.openarchivescholar.com/id/eprint/866

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